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原著 Original Article

Prime Editing Enables Isogenic Modeling of PNPLA3-I148M-Associated Lipotoxicity in Hepatocytes

Haruna Noguchi, Takuro Uchida, Naoki Wakita, Mitsumasa Takenaga, Tetsushi Sakuma, Serami Murakami, Mitsuki Inomata, Atsushi Ono, Hiroko Hagiwara, Yuka Hirashita, Sotaro Ozaka, Kei Mori, Tomoko Tokumaru, Tomoko Saito, Masao Iwao, Mie Arakawa, Mizuki Endo, Masaaki Kodama, Kazuhiro Mizukami

Molecular Therapy Nucleic Acids ： Online now, 102993, June 23, 2026

Anisakis infection induces IgE responses resulting from ILC2 and Th2 cell activation via IL-33 in the murine stomach.

Hidano S, Mizukami K, Shirakami K, Ito H, Matsumura K, Dewayani A, Ozaka S, Saechue B, Ariki S, Ozaki T, Noguchi K, Kagoshima Y, Ekronarongchai S, Okamoto M, Kamiyama N, Sachi N, Sekiya T, Takaki S, Murakami K, Kobayashi T.

Parasitol Int. ： 2026 Apr;111:103184. doi: 10.1016/j.parint.2025.103184. Epub 2025 Oct 14. PMID: 41101719.

EUS-Guided Versus Percutaneous Transhepatic Drainage of Liver Abscesses: A Multicenter Endohepatology Study in Western Japan (EPIC-LA Study).

Ogura T, Kuroda T, Matsuura T, Kitadai J, Kitagawa K, Itonaga M, Takeshita K, Matsumori T, Emori T, Takenaka M, Imai H, Mandai K, Shintani S, Fujimori N, Shiomi H, Asada M, Sagami R, Maruyama H, Ikeura T, Shimatani M, Nishikiori H, Matsumoto K, Kokubu M, Kamada H, Ishida Y, Hakoda A, Kitano M.

Dig Endosc. ： 2026 Jan;38(1):e70067. doi: 10.1111/den.70067. Epub 2025 Nov 27. PMID: 41307348; PMCID: PMC12746055.

Employment Status of Patients With Liver Disease: A Nationwide Questionnaire Survey in Japan

Tokumoto Y, Hiasa Y, Uchida Y, Oono T, Yukimoto A, Watanabe T, Sasaki R, Tatsuki S, Tanaka H, Inoue T, Horino M, Hirose A, Ikegami T, Inoue J, Isoda H, Takahashi H, Arao Y, Hidaka I, Tojima H, Kakizaki S, Shimakami T, Tatemichi M, Kagawa T, Ogawa K, Ohara M, Kozuka R, Enomoto M, Endo M, Eguchi Y, Nagata K, Korenaga M.

Hepatol Res. ： 2026 Feb;56(2):214-222. doi: 10.1111/hepr.70048. Epub 2025 Oct 4. PMID: 41045462.

Comparative Evaluation of Percutaneous Transhepatic Biliary Drainage and Endoscopic Ultrasound-Guided Biliary Drainage for Preoperative Management of Malignant Distal Bile Duct Obstruction After Failed ERCP: A Multicenter Retrospective Analysis.

Itonaga M, Takenaka M, Shiomi H, Kitagawa K, Shintani S, Maruyama H, Sagami R, Ikeura T, Ogura T, Ishida Y, Mandai K, Sugimori S, Imamura Y, Masuda A, Ikezawa K, Shimizu A, Nakai A, Nagai M, Nakano R, Wan K, Shimokawa T, Kitano M.

Dig Endosc. ： 2026 Jan;38(1):e70048. doi: 10.1111/den.70048. Epub 2025 Oct 22. PMID: 41126590.

A CRISPR-based genome-wide loss-of-function screen defines a role of host metabolism in regulating hepatitis B virus infection.

Inuzuka T, Mouzannar K, Zhang M, Umarova R, Park SB, Uchida T, Ma CD, Liang TJ.

Mol Ther. ： 2026 Mar 4;34(3):1616-1632. doi: 10.1016/j.ymthe.2025.11.032. Epub 2025 Dec 1. PMID: 41332134; PMCID: PMC12776588.

症例報告 Case Report

Acute polyarthritis caused by parvovirus B19 mimicking systemic sclerosis.

Kikuna C, Miyagami T, Shindo A, Ukishima S, Aiko W, Nakanishi Y, Uchida T, Naito T.

Am J Med. ： 2026 Feb;139(2):e45-e47. doi: 10.1016/j.amjmed.2025.08.013. Epub 2025 Aug 13. PMID: 40816517.